Human Mammary Epithelial Cell Line

When epithelial cells become malignant become cancerous they form tumors that are referred to as carcinomas.

Human mammary epithelial cell line.

Breast cancer is the most common cancer in women and a leading cause of cancer related deaths for women worldwide. Review of the human mammary epithelial cell hmec culture system last revised january 2003 procedures. Epithelial cells are defined as cells or tissue of the epithelium a thin layer of tissue that covers or lines the surface of tubes or cavities within the body. Human mammary cell types generated.

Various cell models have been developed to study breast cancer tumorigenesis metastasis and drug sensitivity. These cells are ideally suited to support the study of many fields including inflammation cancer gene regulation cell matrix interactions and also have application in toxicology testing and drug screening development. Human mammary epithelial cells were obtained from a healthy individual undergoing reduction. To overcome this problem we have developed a cell line that was immortalized using defined genetic elements and we have characterized this immortalized non tumorigenic human mammary epithelial cell line to establish it as a potential model system.

Biology of the mammary gland provided by the national institute of health labarge lab. Not detected hepatitis c. These cells types are distinct and are the precursors to various forms of breast cancer. The majority of breast cancers originate in the lobular or ductal cells of the milk producing glands.

The inner luminal cells surrounded by basal myoepithelium. Around 80 of cancers in the human. Not detected hepatitis b. Not detected bacteria yeast and othe.

Additional websites of interest for mammary gland biology. Atcc primary cell solutions offers epithelial cells isolated from human breast bronchi trachea and small airways cornea prostate and kidneys. An overview of growth aging senescence and immortality. Primary human mammary epithelial cells cryopreserved at the end of the 6th culture.

The mcf10a human mammary epithelial cell line is a widely used in vitro model for studying normal breast cell function and transformation. In these structures there are two main cell types. Definition of epithelial cells.